**Company Description** Milestone One is a Site Enabling Services organization with global headquarters in Zug, Switzerland. We understand what clinical study sites need and our overall mission is to support sites in stronger study delivery. **Job Description** The Full\-Stack Developer will design, build, and maintain the internal platforms, applications, and integrations that run Milestone One’s business. Our applications have a React/TypeScript front end, an API layer, and a database backend, hosted on Azure and integrated with Microsoft 365\. We work data\-first: we design and document the data structure, build the API from that specification, and then build the front end. You will work in a small team alongside AI coding agents, with security, data protection, and documented testing built into how we deliver. **Role responsibilities:** * Design and document data models and databases (Azure SQL) for our central data platform, internal applications, and reporting * Develop secure REST APIs and backend services (.NET / C\#, Azure App Service or Functions), with access checks in the API and permissions enforced at both the API and data layers * Build React/TypeScript front ends that integrate with our company intranet and follow the Milestone One design system * Build integrations between internal systems and third\-party services (APIs, webhooks, data imports) * Work in GitHub: pull requests, code reviews, GitHub Actions CI/CD, and automated code and secret scanning * Define infrastructure as code with OpenTofu, using Managed Identity and Key Vault instead of stored secrets * Write automated tests with Playwright and support business users during acceptance testing * Use AI coding agents productively and safely, reviewing, testing, and taking ownership of all generated code * Follow our change management and system validation procedures, and keep technical documentation current * Collaborate with stakeholders to shape requirements and turn them into working solutions **Qualifications*** Professional experience building web applications with React/TypeScript and a backend language such as C\# / .NET (we welcome both experienced and early\-career developers) * SQL — schema design, data modelling, and writing efficient queries * REST API design, authentication and authorization (Entra ID, OAuth 2\.0 / OpenID Connect) * Git branching, pull requests, and code review; CI/CD pipelines (GitHub Actions or Azure DevOps) * Azure fundamentals — App Service, Azure SQL, Blob Storage, Key Vault, Managed Identity * Secure coding practices (e.g. OWASP Top 10\) and care for personal and sensitive data * Willingness to work in a regulated environment: change control, testing evidence, audit trails, and data integrity * Fluent in English, written and spoken **Nice to Have** * .NET 8 / C\# — REST API development (Entity Framework or Dapper) * Infrastructure as code with OpenTofu or Terraform * Automated testing with Playwright or similar tools * Professional experience working with AI coding agents or assistants * Azure Functions, Static Web Apps, API Management, Front Door / WAF v2 * Star schema / dimensional modelling (staging dimension fact ETL) * Microsoft Graph API and Microsoft 365 integration * Clinical trial domain knowledge (sites, studies, patients, financial events) * Knowledge of data protection requirements such as GDPR and HIPAA **Additional Information** If you feel it is time to make your skills and knowledge visible within a developing company with true focus on its people, then Milestone One is the right choice for you.